Functions of Tamoxifen Citrate

Tamoxifen Citrate is a molecule created in a lab. It acts as a SERM (Selective Estrogen Receptor Modulator) that is used to combat breast cancer and aid in the prevention of breast cancer in women who are at high risk for development. It is also used to help prevent the risk of breast cancer spreading, in women who have DCIS.

First discovered in 1967, tamoxifen citrate is one of the medicines on the list of the most important medications in the health care system. It was approved by the FDA in the 1970s, and has been used to treat breast cancer since.

Selective Estrogen Receptor Modulator

SERMs are molecules synthesized in the laboratory and have the ability to bind to estrogen receptors in the body. They can act as either agonist or antagonist, effectively inhibiting or stimulating actions involved estrogen.

These types of molecules are used to treat a number of different diseases that involve estrogen. This includes infertility, postmenopausal osteoporosis, and breast cancer. They can also be used to treat estrogen deficiency caused from menopause.

SERMs will actively stimulate estrogenic action in certain tissues. This includes the bone, liver, and cardiovascular system. However, in the breast and uterus it will actively inhibit and block estrogen action.

How does Tamoxifen Citrate work?

This research liquid works by binding to estrogen receptors on breast cancer cells, which are dependent on estrogen to multiply. This blocks the cells from absorbing estrogen, preventing them from being able to turn on singles that rely on estrogen in the DNA; this will prevent the synthesis of the cancer cells, stopping them from having a chance to multiply. Without the ability to have estrogen bind to it, the cancerous cells will eventually starve and die.

This research liquid also blocks another molecule that assist the multiplication of cancers cells, insulin-like growth factor-1 (IGF-1). Tamoxifen citrate has another added benefit of stimulating the synthesis of a molecule that has been known to suppress the development of more cancerous cells. This molecule being transforming growth factor B (TGF-b).

Breast Cancer Prevention

Scientist discovered that tamoxifen citrate could reduce the chances of developing breast cancer by 50%, for women who were at high risk for developing it. It wasn’t until 1998, that Tamoxifen became the first drug approved in the prevention of breast cancer.

Treatment of Breast Cancer

Tamoxifen citrate, sold under the name brand Nolvadex, is the most common research liquid used to treat breast cancer. Currently it is used in the treatment of early and advanced estrogen receptor positive breast cancers. This is in both women that are post and pre-menopausal.  It is used on patients whose cancer has spread to other parts of the body and in some patients after surgery and radiation. Given in tablet form, it comes with the recommended dose being 20-40 mg a day.

Tamoxifen Citrate Side Effects

Since tamoxifen citrate works by blocking estrogen, there are some side effects that are seen. One of the potential effects is the development of endometrial cancer. Due to this, if women experience abnormal vaginal bleeding or pelvic pain while on it, they should contact their physician immediately.

Tamoxifen citrate has the potential to increase your chance of developing liver problems, eye problems, and other serious side effects. Your doctor should be contacted immediately if you experience any of these potentially life threatening side effects:

  • Blurred or tunnel vision, pain in your eyes
  • Changes in your menstrual cycle
  • Pressure/pain in your pelvic
  • A new breast lump
  • Signs of liver problems which include: jaundice (yellowing in your eye or skin), pain in your upper stomach, nausea, feeling tired, loss of appetite, and dark urine
  • Signs of high levels of calcium in blood which include: vomiting, increased thirst, muscle weakness, bone pain, confusion, and tired feeling.

Other side effects include:

  • Hot flashes
  • Irregularities in menstrual cycle
  • Vaginal discharge
  • Increased risk of blood clots and stroke
  • Weight loss
  • Leg cramps
  • Abdominal cramps

Women who are pregnant, or plan on being pregnant should not take tamoxifen citrate, as it can be harmful to the unborn baby. Women should wait at least two months (if not longer) after stopping before attempting to become pregnant.

The development of tamoxifen citrate was an important step in the treatment of breast cancer, and its prevention. This SERM is currently the most common research liquid used in the treatment of this disease. It has the potential to reduce the risk of developing breast cancer by 50% in women who are at high risk for the disease. This type of research liquid gives hope to many who might suffer from this disease.

With the help of research tamoxifen citrate can have more of a major impact on the medical field. These advancements are important to help society live a healthy lifestyle. Rasa Research offers a number of different research liquids and peptides that can assist in your research studies.

All products purchased from Rasa Research are for laboratory and in vitro usage only.

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March 30, 2016 Research Peptides , ,
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